Autophagy

Autophagy is the recycling of damaged cells.

Some autophagy can increase longevity
But too much causes atrophy and decreases lifespan.

study
Starvation-induced autophagy increases longevity in yeast and mammals.

When you get older, autophagy doesn’t work as well.

• why

study

 chronic overnutrition plays a suppressive role of autophagy pathways. It thus remains possible that chronic dietary stress could contribute, in part, to decreased macroautophagy and CMA observed with age

restoration studies with rapamycin or with upregulation of critical regulatory genes have demonstrated that longevity and health-span can potentially be improved by activating these pathways

source

Excess autophagy appears to be detrimental to life by inducing atrophy or generalized loss of cells.

Backlinks¶

• Mammalian target of rapamycin
  • Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body.
• spermidine
  • Spermidine is a calorie restriction mimetics, it activates autophagy